Bioinformatics Analysis
High performance NGS platforms generate massive amounts of data.
ACGT provides comprehensive bioinformatics services and end-to-end solutions to help you interpret it.
Our professional bioinformatics team prides itself on accurate data, reliable output, fast turnaround, and thorough customer support.
Services
See how ACGT Bioinformatics can complete your research goals.
Genome Analysis
Whole Genome Sequencing (WGS) and Targeted Sequencing generate large-scale data that relies on fast, accurate bioinformatics for interpretation.
ACGT Bioinformatics offers reference genome alignment and variant analysis for complete and deep coverage of reference sequence, single-nucleotide variations (SNVs), short insertions and deletions (InDels), and copy number variations (CNVs), important biomarkers for biomedical research and in developing pharmaceutical products.
ACGT Bioinformatics also offers de novo sequence analysis for genome assembly and annotation of non-model organisms, and species with incomplete reference genomes, well suited for plant, animal, and microbial evolution research.
Transcriptome Analysis
Complete transcriptome sequencing has become an important tool in the analysis of gene and allele expression, alternative splice sites, and the discovery of rare/novel transcripts. The entire RNA population within the sample is sequenced by NGS, yielding an unprecedented amount of organizational and structural details of a transcriptome.
ACGT Bioinformatics offers reference genome alignment and variant analysis for complete coverage of the transcript sequence, deep sequencing analysis of SNPs and indels, and accurate evaluation of transcript numbers; de novo sequence analysis for a profiling and quantification of the whole population of RNA in any species – with no prior knowledge of its genome sequence.
ACGT Bioinformatics also offers quantification, differential gene expression analysis, splice variant / novel isoform identification, for gene expression and cell transcriptome research.
Epigenome Analysis
Epigenetics is a rapidly growing field in biology and cancer research, studying the control of how proteins and gene products are expressed. Epigenetic control is often mediated by methylation of cytosine to 5-methylcytosine (5-mC) in CpG islands, but other types of base modifications are possible.
ACGT Bioinformatics offers whole genome bisulfite sequencing (WGBS) and reduced representation bisulfite sequencing (RRBS) analyses for detection and calculation of methylation, comparative methylation analysis, and visualization of methylation profile of the whole genome, or targeted gene promoters and CpG islands.
ACGT Bioinformatics also offers chromatin immunoprecipitation sequencing (ChIP-seq) analysis for motif prediction, peak annotation, functional analysis, and data visualization.
Metagenomics
Metagenomics is the study of microbial communities sampled directly from their natural environment, without prior culturing. By enabling analysis of populations in vivo – including unculturable and unknown microbes – metagenomics is revolutionizing the field of microbiology.
ACGT Bioinformatics offers large-scale shotgun metagenomics, extensive sequencing of the entire meta-genome in the sample followed by de novo partial assembly of individual genomes, and targeted metagenomics, smaller-scale 16S rRNA-based surveys for microbe identification, or acquiring sequence reads with specific protein functions (e.g. antibiotic resistance genes).
Custom Analysis
ACGT Bioinformatics delivers end-to-end bioinformatics solutions customized for your research goals.
ACGT Bioinformatics can work with you in designing workflows according to current best practices, building bespoke software pipelines for your custom NGS analysis, and providing computing and storage resources at your convenience.
Your data matters.
ACGT ensures your data belongs only to you.
ACGT is a 100% U.S.-based company. All generated data is managed and stored onsite, at our headquarter and labs, by dedicated IT and bioinformatics teams.
Deliverable data is encrypted, archived, and purged for security, integrity, and confidentiality.
Software and Tools
ACGT Bioinformatics adheres to current industry standards and stays up-to-date on latest developments.
DRAGEN Bio-IT Platform
open-source and proprietary software for QC and data analysis
